I’m a British science editor and author of a string of books on the scientific, medical, and social implications of advances in genetics research. I trained as a geneticist but found more personal satisfaction wielding a pen rather than a pipette. I’m especially drawn to science stories that have medical implications for the public and a strong narrative thread. Prior to writing Editing Humanity, I covered the race for the BRCA1 breast cancer gene (Breakthrough), the Human Genome Project (Cracking the Genome), and the rise of personal genomics (The $1,000 Genome). I’m currently writing a biography of sickle cell disease, arguably the most famous genetic mutation in human history.
I wrote
Editing Humanity: The CRISPR Revolution and the New Era of Genome Editing
A Crack in Creation was the first mainstream book that conveyed the extraordinary potential and ethical peril of the new genome editing technology, CRISPR. And who better to write it than the scientist who co-developed the “genetic scissors”, Professor Jennifer Doudna (who won the Nobel Prize three years later).
The book is also notable for the candid manner in which Doudna discusses her own nightmares about the potential misuse of CRISPR – fears that erupted one year later in the ‘CRISPR babies’ scandal.
BY THE WINNER OF THE 2020 NOBEL PRIZE IN CHEMISTRY | Finalist for the Los Angeles Times Book Prize
“A powerful mix of science and ethics . . . This book is required reading for every concerned citizen—the material it covers should be discussed in schools, colleges, and universities throughout the country.”— New York Review of Books
Not since the atomic bomb has a technology so alarmed its inventors that they warned the world about its use. That is, until 2015, when biologist Jennifer Doudna called for a worldwide moratorium on the use of the gene-editing tool CRISPR—a revolutionary new…
The CRISPR story took a shocking turn in 2018 when a Chinese scientist attempted the unthinkable – overseeing the birth of twin girls with edited DNA.
I devoted multiple chapters to this saga in my book (resulting in the book’s ban in China); meanwhile, Stanford law professor Hank Greely produced an excellent account of the entire story in CRISPR People. Greely eloquently guides the reader beyond the headlines, offering valuable context and shrewd legal analysis, before asking whether this scandal could happen again.
What does the birth of babies whose embryos had gone through genome editing mean--for science and for all of us?
In November 2018, the world was shocked to learn that two babies had been born in China with DNA edited while they were embryos--as dramatic a development in genetics as the cloning of Dolly the sheep was in 1996. In this book, Hank Greely, a leading authority on law and genetics, tells the fascinating story of this human experiment and its consequences. Greely explains what Chinese scientist He Jiankui did, how he did it, and how the public and other…
I have seldom read a book with as much zeal as The Code Breaker, written by the famous biographer and historian, Walter Isaacson, whom I’d met on the CRISPR conference circuit.
Isaacson focuses on Doudna’s life and science, but also introduces the reader to a large cast of characters, including Doudna’s former colleague and fellow Nobelist, Emmanuelle Charpentier. He even has a crack at running a CRISPR experiment himself.
The success of this book has likely done more than anything to educate the public on the transformative promise of CRISPR.
The best-selling author of Leonardo da Vinci and Steve Jobs returns.
In 2012, Nobel Prize winning scientist Jennifer Doudna hit upon an invention that will transform the future of the human race: an easy-to-use tool that can edit DNA.
Known as CRISPR, it opened a brave new world of medical miracles and moral questions. It has already been deployed to cure deadly diseases, fight the coronavirus pandemic of 2020, and make inheritable changes in the genes of babies.
But what does that mean for humanity? Should we be hacking our own DNA to make us less susceptible to disease? Should…
As both a follow-up and a sort of prequel to his Pulitzer Prize-winning book The Emperor of All Maladies, oncologist Sid Mukherjee wrote another elegant masterpiece in The Gene.
The book unwinds the rich history of genetics research with both substance and an abundance of style, culminating in the discovery of CRISPR and gene editing. It is as good an introduction to the story of DNA and genetics as can be found, one that sets the stage for a variety of therapeutic interventions.
Selected as a Book of the Year by The New York Times, The Economist, Independent, Observer and Mail on Sunday
THE NEW YORK TIMES NUMBER ONE BESTSELLER BBC RADIO 4 BOOK OF THE WEEK
`Dramatic and precise... [A] thrilling and comprehensive account of what seems certain to be the most radical, controversial and, to borrow from the subtitle, intimate science of our time... He is a natural storyteller... A page-turner... Read this book and steel yourself for what comes next' Bryan Appleyard, Sunday Times
The Gene is the story of one of the most powerful and dangerous ideas in our…
British author, broadcaster and zoologist Matthew Cobb has written several books about the history of DNA research.
As Gods (the book’s original UK title is The Genetic Age) is a fast-paced analysis of “the thrilling and terrifying” 50-year history of genetic engineering and the rise of the biotechnology complex. But Cobb also asks tough questions regarding our propensity to meddle with nature, including the 2018 CRISPR babies scandal, reaching the unsettling conclusion that “dreams and nightmares must go hand in hand”.
The thrilling and terrifying history of genetic engineering
In 2018, scientists manipulated the DNA of human babies for the first time. As biologist and historian Matthew Cobb shows in As Gods, this achievement was one many scientists have feared from the start of the genetic age. Four times in the last fifty years, geneticists, frightened by their own technology, have called a temporary halt to their experiments. They ought to be frightened: Now we have powers that can target the extinction of pests, change our own genes, or create dangerous new versions of diseases in an attempt to prevent future…
From the moment I first started paying attention to CRISPR and gene editing, I knew I had to write the story of the CRISPR revolution! Editing Humanity: The CRISPR Revolution and the New Era of Genome Editing was published ironically on the eve of the 2020 Nobel Prize (to Doudna and Charpentier) for their discovery of the “genetic scissors”.
My story has four major themes: 1) the evolution of CRISPR from a bacterial immune system to the most powerful genome editing tool; 2) advances in the clinic leading to a likely cure for sickle cell disease and many other diseases; 3) ethical implications of designer babies and editing human embryos; and 4) myriad applications of CRISPR from plants and crops to hypoallergenic cats and woolly mammoths.
Tap Dancing on Everest, part coming-of-age memoir, part true-survival adventure story, is about a young medical student, the daughter of a Holocaust survivor raised in N.Y.C., who battles self-doubt to serve as the doctor—and only woman—on a remote Everest climb in Tibet.
The team attempts a new route up the East Face without the use of supplemental oxygen, Sherpa support, or chance for rescue. When three climbers disappear during their summit attempt, Zieman reaches the knife edge of her limits and digs deeply to fight for the climbers’ lives and to find her voice.
The plan was outrageous: A small team of four climbers would attempt a new route on the East Face of Mt. Everest, considered the most remote and dangerous side of the mountain, which had only been successfully climbed once before. Unlike the first large team, Mimi Zieman and her team would climb without using supplemental oxygen or porter support. While the unpredictable weather and high altitude of 29,035 feet make climbing Everest perilous in any condition, attempting a new route, with no idea of what obstacles lay ahead, was especially audacious. Team members were expected to push themselves to their…
